Institute for Stem Cell Biology and Regenerative Medicine
Research in the Reijo Pera Lab

Renee Reijo Pera focuses on understanding human embryo growth and development, and on characterizing the basic properties of human embryonic stem cells, especially their ability to generate pluripotent stem cells, somatic cells, and germ cells. Her early work resulted in identification of one of the first genes specifically implicated in human germ cell development. Subsequently, her laboratory has established techniques for differentiation of human embryonic stem cells to germ cells and genetic manipulation of the pathways.

 

Recent Publications

Chung J, Kee K, Barral JK, Dash R, Kosuge H, Wang X, Weissman I, Robbins RC, Nishimura D, Quertermous T, Reijo-Pera RA, Yang PC (2011) In vivo molecular MRI of cell survival and teratoma formation following embryonic stem cell transplantation into the injured murine myocardium. Magn Reson Med. 2011 May 20. doi: 10.1002/mrm.22929. [Epub ahead of print]

Nicholas CR, Haston KM, Grewall AK, Longacre TA, Reijo Pera RA (2009) Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility. Human Molecular Genetics 18:4376-89.

Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA (2009) Human DAZL, DAZ and BOULE genes modulate primordial germ cell and haploid gamete formation. Nature 462, 222-5.

Kee K, Flores M, Cedars MI, Reijo Pera RA. (2010) Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway. Tox. Sci. 117:218-24.

Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Reijo Pera RA. (2010) Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nature Biotechnol 28:1115-21.

Panula S, Medrano JV, Kee K, Bergstrom R, Nguyen HN, Byers B, Wilson KD, Wu JC, Simon C, Hovatta O, Reijo Pera RA (2010) Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells. Hum Mol Genet 20:752-62.

Julaton VT and Reijo Pera RA (2011) NANOS3 function in human germ cell development. Hum Mol Genet 20:2238-50.

HN Nguyen, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schuele B, Dolmetsch RE, Langston W, Palmer TD, Reijo Pera RA (2011) LRRK2 mutant iPSC-Derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 1–14.

LFZ Batista, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug A, Crary S, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE (2011) Telomere shortening and loss of self-renewal in iPSCs from patients with dyskeratosis congenital. Nature 474:399-402.


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