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Research in the Diehn Lab
Our lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. Additionally, we are interested in analyzing and overcoming resistance mechanisms to radiotherapy and chemotherapy in cancer stem cells. The overarching goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells in the clinical setting.
Recent Publications
Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF. "Association of reactive oxygen species levels and radioresistance in cancer stem cells." Nature 2009, 458:780-3. Diehn M, Cho RW, Clarke MF. "Therapeutic implications of the cancer stem cell hypothesis." Semin Radiat Oncol. 2009, 19:78-86.
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