Institute for Stem Cell Biology and Regenerative Medicine
Research in the Beachy Lab

My lab studies the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.

 

Recent Publications

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA. Proc Natl Acad Sci U S A
2011; 108: 4453-8:

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Shin K, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA. Nature
2011; 472: 110-4:

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Proc Natl Acad Sci U S A. 2010; 107 (30): 13432-7

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. Proc Natl Acad Sci U S A. 2010; 107 (13): 5869-74

 


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